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Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

21 August 2019 | Posted by: Etienne Sibille
Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a major depressive episode on the Senescence-Associated Secretory Phenotype (SASP)...View full Article

The diversity of GABAergic neurons and neural communication elements

20 August 2019 | Posted by: Etienne Sibille
The phenotypic diversity of cortical GABAergic neurons is probably necessary for their functional versatility in shaping the spatiotemporal dynamics of neural circuit operations underlying cognition....View full Article

Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors

13 August 2019 | Posted by: Etienne Sibille
α5 subunit containing GABA type A receptors (GABAARs) have long been an enigmatic receptor subtype of interest due to their specific brain distribution, unusual surface localization and key role in synaptic plasticity, cognition and memory...View full Article

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

12 August 2019 | Posted by: Etienne Sibille
The gut microbiome is emerging as a key regulator of several metabolic, immune and neuroendocrine pathways1,2. Gut microbiome deregulation has been implicated in major conditions such as obesity, type 2 diabetes, cardiovascular disease, non-alcoholic fatty acid liver disease ...View full Article

Neuronal Autophagy in Synaptic Functions and Psychiatric Disorders

06 August 2019 | Posted by: Etienne Sibille
Homeostatic maintenance of physiological functions is fundamental to organismal well-being. Disruption or imbalance in homeostasis results in functional disturbances at molecular, cellular, and tissue levels...View full Article

From Many to One to Manythe Search for Causes of Psychiatric Illness

28 June 2019 | Posted by: Etienne Sibille
The search for the causes of medical and psychiatric disorders has gone through 3 historical phases. First, up until the mid-19th century, causes of illness were anecdotally recorded from individual cases, resulting in long and diverse lists for all disorders. Second, in the latter half of the 19th century, with the use of...View full Article

Age Mosaicism across Multiple Scales in Adult Tissues

10 June 2019 | Posted by: Breno Diniz
Most neurons are not replaced during an animals lifetime. This nondividing state is characterized by extreme longevity and age-dependent decline of key regulatory proteins....View full Article

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

10 June 2019 | Posted by: Etienne Sibille
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death 1. Despite rapid advances over recent years...View full Article

I'm Optimistic about Depression

13 May 2019 | Posted by: Etienne Sibille
As Lydia* walked into my office, I could see all was not well with her even before she sat down. She moved slowly, much more so than would be expected for a woman in her early 60s. Her face was impassive and didn't display any of the usual warmth...View full Article

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

13 May 2019 | Posted by: Etienne Sibille
Depression is an episodic form of mental illness, yet the circuit-level mechanisms driving the induction, remission, and recurrence of depressive episodes over time are not well understood....View full Article

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