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16 February 2020 | Posted by:

Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes

18 November 2019 | Posted by: Etienne Sibille
γ-aminobutyric acid (GABA) inhibitory interneurons play a key role in efferent and afferent control of principle neuron activity in the prefrontal cortex (PFC), thereby regulating signal integrity of cognitive and behavioral processes. ...View full Article

Adaptive disinhibitory gating by VIP interneurons permits associative learning

17 November 2019 | Posted by: Etienne Sibille
Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during associative learning has been extensively studied, little is known about the contributions of local interneurons....View full Article

Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

21 August 2019 | Posted by: Etienne Sibille
Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a major depressive episode on the Senescence-Associated Secretory Phenotype (SASP)...View full Article

Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors

13 August 2019 | Posted by: Etienne Sibille
α5 subunit containing GABA type A receptors (GABAARs) have long been an enigmatic receptor subtype of interest due to their specific brain distribution, unusual surface localization and key role in synaptic plasticity, cognition and memory...View full Article

Age Mosaicism across Multiple Scales in Adult Tissues

10 June 2019 | Posted by: Breno Diniz
Most neurons are not replaced during an animals lifetime. This nondividing state is characterized by extreme longevity and age-dependent decline of key regulatory proteins....View full Article

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

10 June 2019 | Posted by: Etienne Sibille
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death 1. Despite rapid advances over recent years...View full Article

I'm Optimistic about Depression

13 May 2019 | Posted by: Etienne Sibille
As Lydia* walked into my office, I could see all was not well with her even before she sat down. She moved slowly, much more so than would be expected for a woman in her early 60s. Her face was impassive and didn't display any of the usual warmth...View full Article

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

13 May 2019 | Posted by: Etienne Sibille
Depression is an episodic form of mental illness, yet the circuit-level mechanisms driving the induction, remission, and recurrence of depressive episodes over time are not well understood....View full Article

Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition

05 May 2019 | Posted by: Etienne Sibille
Auditory stimulation combined with light-induced gamma oscillations in the hippocampus CA1 and auditory cortex regions of the brain reduces amyloid levels and improves memory in animal models of Alzheimer's disease....View full Article

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