Latest Lab Updates

Lifting Brain Fog – Professor Etienne Sibille and Professor James Cook

26 August 2019 | Posted by: Kartikay Chadha
Effective treatments for cognitive dysfunction, such as declines in memory and other mental faculties often associated with depression or old age, may be within reach, according to Professor Etienne Sibille at the Centre for Addiction and Mental Health (CAMH) and the University of Toronto, Canada....View full Article




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Upcoming Lab Meeting

18 November 2019 | 4 pm Friday | Rm 163, 250 College Street Site
Event Type: Lab Meeting
Presenter: Navona Calarco


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GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

03 December 2019 | Posted by: Etienne Sibille
A single sub-anesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders. Ketamine produces a rapid increase in extracellular glutamate and synaptic formation in the prefrontal cortex, but the initial cellular trigger that initiates these and its behavioral actions has not been identified. To address this question, we used a combination of viral shRNA and conditional mutation to produce cell specific knockdown or deletion of a key NMDAR subunit...View full Article

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